Colistin Sulphate has also been used recently to treat ventilator-associated pneumonia (VAP) and bacteremia caused by MDR bacteria, such as P. aeruginosa, K. pneumoniae and A. baumannii. Alhough the use of colistin is considered to be effective, other antibiotics are often used in combination with colistin.
Mainly used for the treatment of gram-negative bacteria (e. coli, etc.) caused by intestinal infection, pseudomonas aeruginosa infection (sepsis, urinary tract infection, burn or wound infection) is also effective.
To have a strong antibacterial effect on gram-negative bacteria, the sensitive bacteria are pseudomonas aeruginosa, escherichia coli, enterobacter, klebsiella, salmonella, shigella, pasteurella and vibrio.Proteus, brucella, sharaea and all gram-positive bacteria were resistant to the drug.More slime molds element class for slow disinfectant, the main role in bacterial cell membranes, when contact with sensitive bacteria, its chemical structure of the free amino (Yang) and phosphate ester of phosphoric acid root on the bacterial cell membrane (with electronegative), increase the permeability of membrane, causing cell of important substances such as amino acids, Piao songs, pyrimidine, K + thereof.It can also affect the function of nucleosomes and ribosomes.It is not easy for bacteria to develop resistance to this product, and there is no cross-resistance with other antibiotics, but there is complete cross-resistance between polymyxin and B.(2) pharmacokinetics: the drug is rarely absorbed when taken internally. After absorption, the drug is poorly distributed in the body and lasts for a short time.Except bile, there was only a small amount in other tissues after 8h, and no residual in all tissues after 16h.After injection, it is widely distributed in the body, with 0.5-1h reaching the peak value in the main tissues, but it is not easy to penetrate into the thoracic cavity, joint cavity and infection foci, and it is also difficult to create cerebrospinal fluid.It could not be detected after 6h except blood, trachea, salivary glands, kidney and urine, and could not be detected after 24h except trachea, kidney and urine.Drug protein binding rate is lower.Mainly through renal excretion, renal insufficiency is easy to accumulate in the body.
About us:
China Sinopharm International (Shanghai) Co., Ltd. is a comprehensive commercial service enterprise centering international pharmaceutical business. It is a wholly-owned subsidiary under China Sinopharm International Corporation and is affiliated to China National Pharmaceutical Group Corporation (referred to as "Sinopharm Group"), a Fortune Global 500. Founded in 1985, the company has an net asset of nearly 200 million yuan. It has complete commercial facilities and 23,000 square meters of properties including an office building and shopping malls in Shanghai's West Nanjing Road commercial area and multiple warehouses.
International business are carried out based on the platforms of Sinopharm Group and Sinopharm International Pharmaceutical and aims to spread China's high-quality pharmaceutical products and services to the world. Through close cooperation with major domestic pharmaceutical companies, high-quality pharmaceutical products and overall solutions are provided to overseas customers. We are a well-known pharmaceutical enterprise in China with partners extending to more than 80 countries and regions around the world.
We have long been focusing on the field of medicine and health. Our main business covers overseas registration and import and export of pharmaceutical products such as preparations, APIs, medical devices and diagnostic reagents; export of pharmaceutical engineering equipment, production lines and technical services; import and export of health products, food additives and plant extracts. In 2017, the company's total import and export volume exceeded 300 million yuan. At present, we have obtained more than 20 overseas registration certificates for preparations, APIs and medical devices and assisted many domestic pharmaceutical companies for access to the international market.
Over the years, the company has always adhered to idea to be "professional, efficient, cohesive, progressive" and undertakes the mission to "create value, serve for customers and cultivate employees".Our strategic goal is to place customers as our center and become a world-class pharmaceutical import and export enterprise.
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