Cefotaxime sodium is a third-generation semi-synthetic cephalosporin. It is not as effective against Gram-positive bacteria as cefazolin. Enterococcus is resistant to this product. It is not effective against penicillin-resistant pneumococci. It has a strong effect on Gram-negative bacteria. Bactericidal activity, antibacterial effect against Escherichia coli, influenza bacillus, Klebsiella pneumoniae, Proteus mirabilis, Salmonella is stronger than cefoperazone, weak or resistant to Bacteroides fragilis, Pseudomonas aeruginosa, Enterobacter cloacae Product is not sensitive.
Cefotaxime is widely distributed in various tissues and body fluids throughout the body. The concentration of the drug in normal cerebrospinal fluid is very low; after application of this product in meningitis patients, the effective concentration can be reached in the cerebrospinal fluid. Bronchial secretions, middle ear discharge, pleural effusion, empyema, ascites, gallbladder wall, bile, bone tissue can also reach effective concentration: this product can enter the fetal blood circulation through the placental barrier, a small amount can also Enter the milk.
Cefotaxime sodium is used for infection of respiratory tract, urinary tract, bones and joints, skin and soft tissues, abdominal cavity, biliary tract, digestive tract, facial features, genitals, etc. caused by sensitive bacteria, infection caused by burns and trauma, and sepsis, central The infection is also effective.
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